Profile of Christine Petit
نویسنده
چکیده
Over the last 20 years, geneticist and neurobiologist Christine Petit has written the canticle of the cochlea from scratch, revealing the long-shrouded machinery of the auditory system molecule by molecule. Along the way, she has identified more than 20 genes responsible for hearing impairments, with each of these cochlear deficits accounting for the observed sensory impairment, a succinct story that seemed to stop at the cochlea (1, 2). As Petit, a professor at the Collège de France and Institut Pasteur in Paris, explains, “the proteins encoded by these deafness genes were therefore implicitly considered as nonessential for the central auditory system.” In her Inaugural Article (3), Petit, elected to the National Academy of Sciences in 2016, challenges this view by looking deep into the brain and demonstrating that two adhesion proteins at the heart of the mechanoelectrical transduction machinery of the auditory apparatus also play a role in the embryonic migration of neurons to the auditory cortex. This discovery suggests that treating or compensating for hearing impairment with cochlear interventions, like implants, stem cells, or gene therapy, may not be sufficient to restore optimal hearing.
منابع مشابه
Complete Genome Sequences of Pseudomonas aeruginosa Phages vB_PaeP_PcyII-10_P3P1 and vB_PaeM_PcyII-10_PII10A
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متن کاملThe giant spectrin bV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route
InstitutPasteur,Unité degénétiqueetphysiologiede l’audition,ParisF75015,France InsermUMRS1120,Paris,France UPMC, Paris 6, France Institut Pasteur, PFID-Imagopole, Paris, France Institut de la vision, Syndrome de Usher et autres atteintes rétino-cochléaires, Paris, France Institute of Zoology, Cell and Matrix Biology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany Collège de France...
متن کاملWrapping up Stereocilia Rootlets
The actin-filled stereocilia of cochlear hair cells deflect in response to sound by pivoting around rootlets at their insertion points at the sensory cell surface. Kitajiri et al. (2010) now show that the actin-binding protein TRIOBP tightly bundles the actin filaments into rootlets, endowing these stereocilia "pivots" with unique elasticity and robustness.
متن کاملگزارش یک مورد فتق تروماتیک کمری از نوع کوچک (Petit )
چکیده فتق کمری از فتقهای نادر است که بعلت ضعف جدار خلفی شکم در فضای کمری بوجود میآید و شایعترین محل ایجاد آن در مثلث تحتانی فضای آناتومیک کمری Petit's triangle است.تاکنون بیش از 300 مورد آن در جهان گزارش نشده است . در این مقاله ما به گزارش یکی از موارد نادر و جالب این نوع فتق که بدنبال برداشتن گرافت استخوانی از ستیغ استخوان ایلیاک عارض شده است میپردازیم. در این گزارش بیمار مردی است 60 س...
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تاریخ انتشار 2017